A novel experimental model to investigate fungal involvement shows expression of Dectin-1 in periapical lesion pathogenesis.

Arshad HasanTalat RoomeMohsin WahidShazia Akbar AnsariJaveria Ali KhanAmber KiyaniSyeda Neha Jilani

Published in: Journal of oral rehabilitation (2023)

Immune cells of inflamed periapical tissue expressed Dectin-1 receptor in response to the microbial challenge from infected root canals and showed positive correlation with TLR-2 and OPN suggesting a possible receptor collaboration mediated by OPN. The expression of OPN and TNF-α showed positive correlation in response to fungal antigen, indicating a possible relationship.

Keyphrases

poor prognosis
binding protein
rheumatoid arthritis
inflammatory response
toll like receptor
microbial community
immune response
long non coding rna
cell wall
cone beam computed tomography