60-Day PNS Treatment May Improve Identification of Delayed Responders and Delayed Non-Responders to Neurostimulation for Pain Relief.

Ramana K Naidu Sean LiMehul J DesaiSamir ShethNathan D Crosby Joseph W Boggs

Published in: Journal of pain research (2022)

An extended, 60-day PNS treatment may help identify delayed responders, providing the opportunity for sustained relief and improving access to effective PNS treatment. Compared to a conventionally short trial of ≤10 days, a longer 60-day PNS treatment may also help reduce explant rates by identifying delayed non-responders unlikely to benefit long-term. These scenarios support the importance of an extended 60-day temporary PNS stimulation period to help inform stepwise treatment strategies that may optimize outcomes and cost-effectiveness.

Keyphrases

randomized controlled trial
chronic pain
metabolic syndrome
climate change
combination therapy
study protocol