The involvement of E3 ubiquitin ligases in the development and progression of colorectal cancer.
Jie ChenHaimei FengYiting WangXiaoming BaiSiqi ShengHuiyu LiMengxi HuangXiao-Yuan ChuZengjie LeiPublished in: Cell death discovery (2023)
To date, colorectal cancer (CRC) still has limited therapeutic efficacy and poor prognosis and there is an urgent need for novel targets to improve the outcome of CRC patients. The highly conserved ubiquitination modification mediated by E3 ubiquitin ligases is an important mechanism to regulate the expression and function of tumor promoters or suppressors in CRC. In this review, we provide an overview of E3 ligases in modulating various biological processes in CRC, including proliferation, migration, stemness, metabolism, cell death, differentiation and immune response of CRC cells, emphasizing the pluripotency of E3 ubiquitin ligases. We further focus on the role of E3 ligases in regulating vital cellular signal pathways in CRC, such as Wnt/β-catenin pathway and NF-κB pathway. Additionally, considering the potential of E3 ligases as novel targets in the treatment of CRC, we discuss what aspects of E3 ligases can be utilized and exploited for efficient therapeutic strategies.
Keyphrases
- poor prognosis
- cell death
- immune response
- long non coding rna
- signaling pathway
- stem cells
- small molecule
- induced apoptosis
- cell cycle arrest
- end stage renal disease
- ejection fraction
- prognostic factors
- oxidative stress
- epithelial mesenchymal transition
- cell proliferation
- toll like receptor
- transcription factor
- risk assessment
- inflammatory response
- lps induced
- patient reported outcomes
- climate change