Multicentre study and systematic review: Allopurinol exposure during pregnancy.

Femke CrouwelMelek SimsekMarjon A de BoerDirk P van AsseldonkAbha BhallaAngelique L M WeusthuisLennard P L GilissenRobert J VerburgWout G N MaresBindia JharapJohan P KuijvenhovenBas OldenburgHans J C BuiterMette JulsgaardNanne K de Boer

Published in: Alimentary pharmacology & therapeutics (2024)

Overall, the teratogenicity of allopurinol remains inconclusive. Children conceived by mothers treated for IBD with allopurinol/thiopurine co-therapy do not seem to have an increased risk of congenital anomalies.

Keyphrases

systematic review
meta analyses
young adults
randomized controlled trial
mesenchymal stem cells
bone marrow
cell therapy