Dorsomorphin attenuates Jagged1-induced mineralization in human dental pulp cells.

Jeeranan ManokawinchokeThiphon WatcharawipasKamoltham EkmetipunthManoch JiamjirachartThanaphum Osathanon

Published in: International endodontic journal (2021)

Notch signalling activation by Jagged1 modulated TGF-β and BMP ligand expression. Dorsomorphin, but not TGF-β receptor inhibitor, attenuated Jagged1-induced osteogenic differentiation in hDPs.

Keyphrases

high glucose
endothelial cells
mesenchymal stem cells
diabetic rats
induced apoptosis
transforming growth factor
poor prognosis
bone marrow
drug induced
oxidative stress
induced pluripotent stem cells
epithelial mesenchymal transition
signaling pathway
cell death
endoplasmic reticulum stress