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Intestine-derived α-synuclein initiates and aggravates pathogenesis of Parkinson's disease in Drosophila.

Wei LiuKah-Leong LimEng-King Tan
Published in: Translational neurodegeneration (2022)
The intestinal expression of α-syn recapitulates many phenotypic and pathologic features of PD, and induces dysbiosis that aggravates the pathology through the DUOX-ROS-JNK pathway in Drosophila. Our findings provide new insights into the role of intestinal α-syn in PD pathophysiology.
Keyphrases
  • cell death
  • poor prognosis
  • signaling pathway
  • neoadjuvant chemotherapy
  • dna damage
  • reactive oxygen species
  • locally advanced
  • induced apoptosis
  • binding protein
  • radiation therapy
  • long non coding rna
  • rectal cancer