A TCR-like CAR Promotes Sensitive Antigen Recognition and Controlled T-cell Expansion Upon mRNA Vaccination.
Matthias BirtelRalf-Holger VossKatharina ReinhardBenjamin RengstlYasmina OuchanKristina MichelNina HaydukBodo TillmannRené BeckerMartin SuchanMatthias TheobaldPetra OehmÖzlem TüreciUğur ŞahinPublished in: Cancer research communications (2022)
A novel TCAR is tightly controlled by RNA vaccine-mediated costimulation and may provide an alternative to second-generation CARs for the treatment of solid tumors.