The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children-Analyses based on path models.
Maike WoltersCarmen DeringAlfonso SianiPaola RussoJaakko KaprioPatrizia RiséLuis A MorenoStefaan De HenauwKirsten MehligToomas VeidebaumDenés MolnárMichael TornaritisLicia IacovielloYannis PitsiladisClaudio GalliRonja ForaitaClaudia Börnhorstnull nullPublished in: PloS one (2017)
Genetic variation in FADS1 influences BP via ARA and BMI indicating a favorable effect of the minor allele in SNP rs174546. Thus, polymorphisms with an impact on the D5D activity may play a role for the BP level mediated through PUFA and BMI. Therefore, health effects of dietary n-6 and n-3 PUFA may vary depending on genetic FADS1 variants.