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Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development.

Deepa NakmodeValamla BhavanaPradip ThakorJitender MadanPankaj Kumar SinghShashi Bala SinghJessica M RosenholmKuldeep Kumar BansalNeelesh Kumar Mehra
Published in: Pharmaceutics (2022)
Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product development. The use of lipids in designing formulations provides an opportunity to enhance the aqueous solubility and consequently bioavailability of drugs. Pre-dissolution of drugs in lipids, surfactants, or mixtures of lipid excipients and surfactants eliminate the dissolution/dissolving step, which is likely to be the rate-limiting factor for oral absorption of poorly water-soluble drugs. In this review, we exhaustively summarize the lipids excipients in relation to their classification, absorption mechanisms, and lipid-based product development. Methodologies utilized for the preparation of solid and semi-solid lipid formulations, applications, phase behaviour, and regulatory perspective of lipid excipients are discussed.
Keyphrases
  • fatty acid
  • water soluble
  • ionic liquid
  • machine learning
  • deep learning
  • transcription factor
  • drug induced