A low-oxygen (hypoxia) tumor microenvironment can facilitate chemotherapy and radiation therapy resistance in tumors and is associated with a poor prognosis. Hypoxia also affects PCa (prostate cancer) phenotype transformation and causes therapeutic resistance. Although O-glycans are known to be involved in the malignancy of various cancers under hypoxia, the expression and function of O-glycans in PCa are not well understood. In this study, the saccharide primer method was employed to analyze O-glycan expression in PCa cells. Results showed that the expression of sTn antigens was increased in PCa cells under hypoxia. Furthermore, it was found that ST6GalNAc1, the sTn antigen synthase gene, was involved in the migration-proliferation dichotomy and drug resistance in PCa cells under hypoxia. The results of this study will contribute to the development of novel diagnostic markers and drug targets for PCa under hypoxia.
Keyphrases
- poor prognosis
- induced apoptosis
- endothelial cells
- prostate cancer
- long non coding rna
- radiation therapy
- cell cycle arrest
- signaling pathway
- genome wide
- emergency department
- dna methylation
- gene expression
- radical prostatectomy
- binding protein
- transcription factor
- immune response
- cell proliferation
- copy number
- young adults
- genome wide identification
- genome wide analysis
- childhood cancer