Longitudinal Relationships of White Matter Hyperintensities and Alzheimer Disease Biomarkers Across the Adult Lifespan.
Jingqin R LuoYinjiao MaFolasade Jane AgboolaElizabeth GrantJohn C MorrisEric McDadeAnne M FaganTammie L S BenzingerJason HassenstabRandell J BatemanRichard J PerrinBrian A GordonManu GoyalJeremy F StrainIgor YakushevGregory S DayChengjie Xiongnull nullPublished in: Neurology (2023)
Longitudinal increases in WMH volume started to accelerate around a baseline age of 60.46 years, and correlated with the longitudinal change in PET amyloid uptake, MRI structural outcomes, and cognition.