MEK1/2 Inhibitor (GDC0623) Promotes Osteogenic Differentiation of Primary Osteoblasts Inhibited by IL-1 β through the MEK-Erk1/2 and Jak/Stat3 Pathways.

Zeng-Qiao ZhangXiao-Shen HuYe-Chen LuJun-Peng ZhangWen-Yao LiWei-Yang ZhangWei FengDao-Fang Ding Jian-Guang Xu

Published in: International journal of endocrinology (2021)

Inhibition of Jak-Stat3 pathway by C188-9 downregulated the expression levels of MMP9 and MMP13, activated MEK-Erk1/2 pathway, and inhibited osteogenic differentiation.

Keyphrases

pi k akt
signaling pathway
cell proliferation
poor prognosis
mesenchymal stem cells
cell migration
bone marrow