Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses.
Liam GazianoLuanluan SunMatthew ArnoldSteven BellKelly ChoStephen K KaptogeRebecca J SongStephen BurgessDaniel C PosnerKatja MosconiCassianne Robinson-CohenAmy M MasonThomas R BoltonRan TaoElias AllaraPetra SchubertLingyan ChenJames R StaleyNatalie StaplinServet AltayPilar AmianoVolker ArndtJohan ÄrnlövElizabeth Laurel Mary BarrCecilia BjörkelundJolanda M A BoerHermann BrennerEdoardo CasigliaPaolo ChiodiniJackie A CooperJosef CoreshAndrea N EdgintonRachel DanknerKarina W DavidsonRenate T de JonghChiara DonfrancescoGunnar EngströmHeinz FreislingAgustín Gómez de la CámaraVilmundur G GudnasonGraeme J HankeyPer-Olof HanssonAlicia K HeathEwout J HoornHironori ImanoSimerjot K JassalRudolf KaaksVerena A KatzkeJussi KauhanenStefan KiechlWolfgang KoenigRichard A KronmalCecilie KyroDeborah A LawlorBörje LjungbergConor James MacDonaldGiovanna MasalaChrista MeisingerOlle MelanderConchi Moreno IribasToshiharu NinomiyaDorothea NitschBørge Grønne NordestgaardN Charlotte Onland-MoretLuigi PalmieriDafina PetrovaJose Ramón Quirós GarciaAnnika RosengrenCarlotta SacerdoteMasaru SakuraiCarmen SantiusteMatthias Bernd SchulzeSabina SieriJohan SundströmValérie TikhonoffAnne TjønnelandTammy Y N TongRosario TuminoJoanna TzoulakiYvonne T van der SchouwW M Monique VerschurenHenry VölzkeRobert B WallaceSasiwarang Goya WannametheeElisabete WeiderpassPeter WilleitMark WoodwardKazumasa YamagishiRaul Zamora RosElvis A AkwoSaiju PyarajanDavid R GagnonPhilip S TsaoSumitra MuralidharTodd L EdwardsScott M DamrauerJacob JosephLisa PennellsPeter W F WilsonSeamus HarrisonThomas Andrew GazianoMichael InouyeColin BaigentJuan P CasasClaudia LangenbergNicholas J WarehamElio RiboliJ Michael GazianoJohn DaneshAdriana M HungAdam S ButterworthAngela M WoodEmanuele Di Angelantonionull nullPublished in: Circulation (2022)
In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function.