Differential Gene Expression Analysis of Human Ovarian Follicular Cumulus and Mural Granulosa Cells Under the Influence of Insulin in IVF Ovulatory Women and Polycystic Ovary Syndrome Patients Through Network Analysis.
Pankaj PantHavagiray R ChitmeReema SircarRitu PrasadHari Om PrasadPublished in: Endocrine research (2023)
This is a pioneering investigation aimed to establish the link between hyperinsulinemia in localized follicular GCs and PCOS mechanisms by comparing them to control group. The examination of various attributes, mechanisms, and traits shown by genes and proteins in individuals with PCOS compared to control populations, alongside the investigation of the dynamics of these genes and proteins following exposure to insulin, holds promise for the formulation of novel hypotheses and strategies in the identification of new biomarkers.
Keyphrases
- polycystic ovary syndrome
- insulin resistance
- gene expression
- network analysis
- type diabetes
- genome wide
- end stage renal disease
- bioinformatics analysis
- dna methylation
- induced apoptosis
- chronic kidney disease
- ejection fraction
- newly diagnosed
- endothelial cells
- glycemic control
- prognostic factors
- drug delivery
- adipose tissue
- peritoneal dialysis
- pregnant women
- cell cycle arrest
- genome wide identification
- endoplasmic reticulum stress
- cell proliferation
- patient reported outcomes
- oxidative stress
- cell death
- deep learning
- patient reported
- pluripotent stem cells