Inhibition of the skeletal muscle Lands cycle ameliorates weakness induced by physical inactivity.

Justin L ShahtoutHiroaki EshimaPatrick J FerraraJ Alan MaschekJames E CoxMicah J DrummondKatsuhiko Funai

Published in: Journal of cachexia, sarcopenia and muscle (2023)

Our findings demonstrate that attenuation of skeletal muscle lipid hydroperoxides is sufficient to restore its function, in particular a protection from reduction in muscle specific force. Our findings suggest muscle lipid peroxidation contributes to atrophy and weakness induced by disuse in mice.

Keyphrases

skeletal muscle
insulin resistance
fatty acid
high fat diet induced
physical activity
mental health
single molecule
mouse model
metabolic syndrome