Diaporone A, a new antibacterial secondary metabolite from the plant endophytic fungus Diaporthe sp.
Longfang GuoShubin NiuShuanglin ChenLing LiuPublished in: The Journal of antibiotics (2019)
Diaporone A (1), one new dihydroisocoumarin derivative and four known α-dibenzopyrones, alternariol (2), 5'-hydroxyalternariol (3), alternariol 4,10-dimethyl ether (4), and alternariol 4-methyl ether (5) were isolated from the crude extract of the plant endophytic fungus Diaporthe sp. Their structures were determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESIMS and comparison with data from the literature. The absolute configuration of 1 was assigned by electronic circular dichroism (ECD) calculations. Compound 1 showed moderate antibacterial activity against Bacillus subtilis with the MIC value of 66.7 μM, and exhibited weak cytotoxicity against human cervical carcinoma (HeLa) cell line with IC50 value of 97.4 μM.
Keyphrases
- bacillus subtilis
- high resolution
- endothelial cells
- silver nanoparticles
- systematic review
- magnetic resonance
- molecular docking
- ionic liquid
- electronic health record
- density functional theory
- molecular dynamics simulations
- anti inflammatory
- oxidative stress
- molecular dynamics
- cell wall
- big data
- pluripotent stem cells
- solid state
- cell cycle arrest
- artificial intelligence
- clinical evaluation