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Genetic Association between Lipid-Regulating Drug Targets and Diabetic Retinopathy: A Drug Target Mendelian Randomization Study.

Shengnan ChenMing ZhangPeng YangJianbin GuoLin LiuZhi YangKai Nan
Published in: Journal of lipids (2024)
This is the first study to reveal a genetically causal relationship between lipid-regulating drug targets and DR risk. PCSK9-mediated LDL-C levels maybe positively associated with DR risk at the genetic level. This study provides suggestive evidence that PCSK9 inhibition may reduce the risk of DR.
Keyphrases
  • diabetic retinopathy
  • genome wide
  • emergency department
  • fatty acid
  • optical coherence tomography
  • copy number
  • adverse drug
  • editorial comment