Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma.
Zoe HallDavide ChiarugiEvelina CharidemouJack LeslieEmma ScottLuca PellegrinetMichael AllisonGabriele MocciaroQuentin Mark AnsteeGerard I EvanMatthew HoareAntonio Vidal-PuigFiona OakleyMichele VaccaJulian Leether GriffinPublished in: Hepatology (Baltimore, Md.) (2020)
Overall, we demonstrate that specific lipid metabolic pathways are coherently altered when hepatocytes switch to proliferation. These represent a source of targets for the development of therapeutic strategies and prognostic biomarkers of HCC.