Overexpression of MTA1 inhibits the metastatic ability of ZR-75-30 cells in vitro by promoting MTA2 degradation.
Long ZhangQi WangYuzhen ZhouQianwen OuyangWeixing DaiJianfeng ChenPeipei DingLing LiXin ZhangWei ZhangXinyue LvLuying LiPingzhao ZhangGuoxiang CaiWeiguo HuPublished in: Cell communication and signaling : CCS (2019)
MTA1 and MTA2 play opposing roles in the metastasis of ZR-75-30 luminal B breast cancer cells in vitro. MTA1 downregulates MTA2 at the protein level by epigenetically repressing the expression of elafin and releasing the inhibition of neutrophil elastase, which cleaves MTA2 in the C-terminus at multiple specific sites.