Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial.

Bradley WibrowF Eduardo MartinezErina MyersAndrew ChapmanEdward LittonKwok M HoAdrian RegliDavid HawkinsAndrew FordFrank M P van HarenSimon WyerJoe McCaffreyAlan RashidErin KeltyKevin MurrayMatthew Anstey

Published in: Intensive care medicine (2022)

Enteral melatonin initiated within 48 h of ICU admission did not reduce the prevalence of delirium compared to placebo. These findings do not support the routine early use of melatonin in the critically ill.

Keyphrases

cardiac surgery
hip fracture
emergency department
intensive care unit
risk factors
randomized controlled trial
mechanical ventilation
clinical trial
anti inflammatory
phase iii