Randomized controlled trial of 8 weeks' vs 12 weeks' interval between neoadjuvant chemoradiotherapy and surgery for locally advanced rectal cancer.
C TerziM BingulNaciye Çiğdem ArslanE OzturkA E CandaO IsikT YilmazlarF ObuzI Birkay GorkenM KurtM UnluN UgrasO KanatI OztopPublished in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2019)
Extending the interval between CRT and surgery from 8 to 12 weeks resulted in a 2-fold increase in pCR rate without any difference in mortality and morbidity.
Keyphrases
- rectal cancer
- locally advanced
- minimally invasive
- randomized controlled trial
- coronary artery bypass
- gestational age
- surgical site infection
- study protocol
- squamous cell carcinoma
- cardiovascular events
- lymph node
- radiation therapy
- type diabetes
- systematic review
- acute coronary syndrome
- cardiac resynchronization therapy
- atrial fibrillation