multimedia: Multimodal Mediation Analysis of Microbiome Data.
Hanying JiangXinran MiaoMargaret W ThairuMara BeebeDan W GrupeRichard J DavidsonJo HandelsmanKris SankaranPublished in: bioRxiv : the preprint server for biology (2024)
Microbiome studies routinely gather complementary data to capture different aspects of a microbiome's response to a change, such as the introduction of a therapeutic. Mediation analysis clarifies the extent to which responses occur sequentially via mediators, thereby supporting causal, rather than purely descriptive, interpretation. multimedia is a modular R package with close ties to the wider microbiome software ecosystem that makes statistically rigorous, flexible mediation analysis easily accessible, setting the stage for precise and causally informed microbiome engineering.