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multimedia: Multimodal Mediation Analysis of Microbiome Data.

Hanying JiangXinran MiaoMargaret W ThairuMara BeebeDan W GrupeRichard J DavidsonJo HandelsmanKris Sankaran
Published in: bioRxiv : the preprint server for biology (2024)
Microbiome studies routinely gather complementary data to capture different aspects of a microbiome's response to a change, such as the introduction of a therapeutic. Mediation analysis clarifies the extent to which responses occur sequentially via mediators, thereby supporting causal, rather than purely descriptive, interpretation. multimedia is a modular R package with close ties to the wider microbiome software ecosystem that makes statistically rigorous, flexible mediation analysis easily accessible, setting the stage for precise and causally informed microbiome engineering.
Keyphrases
  • social support
  • electronic health record
  • climate change
  • big data
  • machine learning
  • pain management
  • chronic pain
  • human health
  • artificial intelligence
  • case control