A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition.

A Ni(ii)-catalyzed enantioselective Michael addition of 2-acetyl azarenes with β-difluoromethyl substituted nitroalkenes was successfully realized, which afforded chiral CF 2 H-containing compounds in good enantioselectivities (up to 93% ee ). This protocol provides a new convenient approach to all-carbon quaternary stereogenic centers featuring a CF 2 H group.