Effects of selective serotonin reuptake inhibitors on DNA damage in patients with depression.

Mahnaz AhmadimaneshMohammad Reza AbbaszadeganDorsa Morshedi RadSeyed Adel MoallemAmir Hooshang MohammadpourMohammad Hossein GhahremaniFarhad Farid HosseiniFatemeh BehdaniAli Akhondpour ManteghiPaul JowseyFatemeh Shabani BehbahaniSeyed Mohammad Hassan MoallemLeila Etemad

Published in: Journal of psychopharmacology (Oxford, England) (2019)

This is the first study on the effect of SSRIs on the DNA damage and some of the repair enzymes in depression. Based on the results, depression can cause increased DNA damage. This damage is followed by activation of compensatory mechanisms whereby the expression of DNA damage repair enzymes is elevated. Finally, the treatment of psychiatric disorder by antidepressants can lower the level of oxidative DNA damage.

Keyphrases

dna damage
oxidative stress
dna repair
depressive symptoms
sleep quality
poor prognosis
major depressive disorder
combination therapy