Cardiomuscular Biomarkers in the Diagnosis and Prognostication of Immune Checkpoint Inhibitor Myocarditis.
Lorenz H LehmannMarkus B HeckmannGuillaume BaillyDaniel FinkeAdrien ProcureurJohn R PowerFrederic SteinMarie BretagneStéphane EderhyCharlotte FeniouxOmar HamwyElisa Funck-BrentanoEmanuela RomanoLaurence PieroniJan MünsterYves AllenbachCéline AnquetilSarah Leonard-LouisNicolas L PalaskasSalim Salim HayekHugo A KatusEvangelos GiannitsisNorbert FreyZiya KayaJavid J MoslehiEdi PriftiJoe-Elie Salemnull nullPublished in: Circulation (2023)
cTnT is associated with MACE and is sensitive for diagnosis and surveillance in patients with ICI myocarditis. A cTnT:URL ratio <32 within 72 hours of diagnosis is associated with a subgroup at low risk for MACE. Potential differences in diagnostic and prognostic performances between cTnT and cTnI as a function of the assays used deserve further evaluation in ICI myocarditis.