Covalent Rescue of Mutant p53.

Published in: Cancer discovery (2023)

p53 mutant proteins are widely expressed in human cancer. In this issue, Guiley and Shokat describe the development of compounds that rescue the function of the Y220C mutant p53 protein by forming covalent complexes with the target protein. See related article by Guiley and Shokat, p. 56 (3).

Keyphrases

wild type
endothelial cells
protein protein
papillary thyroid
amino acid
binding protein
squamous cell
squamous cell carcinoma
small molecule
drug induced