Gut microbiota and short-chain fatty acid alterations in cachectic cancer patients.
Jorne UbachsJanine ZiemonsZita SoonsRomy AarnoutseDavid P J van DijkJohn PendersArdy van HelvoortMarjolein L SmidtRoy F P M KruitwagenLieke Baade-CorpelijnSteven W M Olde DaminkSander S RensenPublished in: Journal of cachexia, sarcopenia and muscle (2021)
This clinical study provided the first insights into the alterations of gut microbiota composition and SCFA levels that occur in cachectic cancer patients and how they are related to inflammatory parameters. These results pave the way for further research examining the role of the gut microbiota in cancer cachexia and its potential use as therapeutic target.