Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth.

Arabinda DasM AlshareefF HendersonJ L Martinez SantosW A VandergriftS M LindhorstA K VarmaL InfingerS J PatelD Cachia

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2019)

GA-A/DM may be a promising natural therapeutic reagent in the treatment of AM by suppressing growth via NDRG2 modulation and altering of intracellular signal pathways. We have shown it could potentially be an effective treatment for AM with decreased cellular proliferation in vitro, decreased tumor volume and increased survival in vivo.

Keyphrases

high grade
signaling pathway
poor prognosis
type diabetes
metabolic syndrome
high glucose
long non coding rna
diabetic rats
binding protein
glycemic control
reactive oxygen species
optical coherence tomography
weight loss