Skeletal muscle hypertrophy rewires glucose metabolism: An experimental investigation and systematic review.
Philipp BaumertSakari MäntyselkäMartin SchönfelderMarie HeiberMika Jos JacobsAnandini SwaminathanPetras MinderisMantas DirmontasKarin KleigreweChen MengMichael GiglIldus I AhmetovTomas VenckunasHans DegensAivaras RatkeviciusJuha J HulmiHenning WackerhagePublished in: Journal of cachexia, sarcopenia and muscle (2024)
Understanding the mechanisms that regulate skeletal muscle mass will help in developing effective treatments for muscle weakness. Our results provide evidence for the metabolic rewiring of glycolytic intermediates into anabolic pathways during muscle growth, such as in serine synthesis.