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Late recurrent gastric carcinoma 12 years after surgery with attenuation of CD44 variant 9 expression.

Hirokatsu HayashiItaru YasufukuToshiya HigashiWakana ChikaishiRyoma YokoiMasahiro FukadaYuta SatoRyuichi AsaiJesse Yu TajimaChiemi SaigoAkitaka MakiyamaYoshihiro TanakaNaoki OkumuraKatsutoshi MuraseTakao TakahashiManabu FutamuraTamotsu TakeuchiNobuhisa Matsuhashi
Published in: Surgical case reports (2023)
A defense mechanism against reactive oxygen species has been reported as a mechanism causing recurrence of CD44v9-positive gastric cancer. Consequently, CD44v9-positive gastric cancer grows in metastatic organs, repeatedly self-renews, and proliferates to form recurrent lesions. In the present case, the degree of CD44v9 staining in recurrent lesions was suggested to be related to the recurrence time.
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