Glycine Effect on the Expression Profile of Orphan Receptors GPR21, GPR26, GPR39, GPR82 and GPR6 in a Model of Inflammation in 3T3-L1 Cells.

Rocío Alejandra Gutiérrez-RojasKarla Aidee Aguayo-CerónCruz Vargas-De-LeónSandra Edith Cabrera-BecerraJulio Cesar Almanza-Pérez Fengyang HuangSantiago VillafañaRodrigo Romero-Nava

Published in: Life (Basel, Switzerland) (2022)

Our results suggest that GPR21 and GPR82 are modulated by glycine, it shows a possible protective role in the presence of an inflammatory environment in adipocytes, and they could be a therapeutic target to decrease the inflammation in some diseases related to low-grade inflammation such as diabetes, obesity and metabolic syndrome.

Keyphrases

fatty acid
metabolic syndrome
oxidative stress
low grade
type diabetes
insulin resistance
induced apoptosis
cardiovascular disease
adipose tissue
weight loss
cell death
physical activity
weight gain
high fat diet induced