Glycine Effect on the Expression Profile of Orphan Receptors GPR21, GPR26, GPR39, GPR82 and GPR6 in a Model of Inflammation in 3T3-L1 Cells.
Rocío Alejandra Gutiérrez-RojasKarla Aidee Aguayo-CerónCruz Vargas-De-LeónSandra Edith Cabrera-BecerraJulio Cesar Almanza-PérezFengyang HuangSantiago VillafañaRodrigo Romero-NavaPublished in: Life (Basel, Switzerland) (2022)
Our results suggest that GPR21 and GPR82 are modulated by glycine, it shows a possible protective role in the presence of an inflammatory environment in adipocytes, and they could be a therapeutic target to decrease the inflammation in some diseases related to low-grade inflammation such as diabetes, obesity and metabolic syndrome.