Impact of human placental derivative allografts on functional and oncological outcomes after radical prostatectomy: a literature review.
Jonathan NoëlSubuhee AhmedAnya MascarenhasDaniel StirtMarcio MoschovasEla PatelSunil ReddySeetharam BhatTravis RogersVipul PatelPublished in: Journal of robotic surgery (2022)
Post radical prostatectomy (RP) erectile dysfunction and incontinence impacts quality of life for patients. In an objective to hasten the recovery of these functional outcomes, human placental derived allografts laid on neurovascular bundles (NVB) have been investigated. These grafts include amniotic membranes (AM) chorionic membranes (CM) or umbilical cord (UC) allografts. A literature review performed using the MeSH terms "AMNION" OR "CHORION" OR "AMNIOTIC MEMBRANE" OR "UMBILICAL CORD" AND "PROSTATE CANCER" from no specified start date, to April 2022. 163 articles were retrieved, with 149 articles excluded. 14 articles were eligible and analysed. 5 articles were included in this review for an analysis on comparative outcomes. The average return to potency was statistically significant in the intervention groups. Positive surgical margin (PSM) rates showed a higher rate in the control groups. BCR was observed at a lower rate in the interventional group. This review reveals a benefit from human placental allograft's ability to hasten post RP functional recovery, without impacting oncological control.
Keyphrases
- chronic kidney disease
- radical prostatectomy
- end stage renal disease
- prostate cancer
- umbilical cord
- mesenchymal stem cells
- endothelial cells
- induced pluripotent stem cells
- pluripotent stem cells
- case report
- acute lymphoblastic leukemia
- type diabetes
- newly diagnosed
- weight loss
- rectal cancer
- metabolic syndrome
- prognostic factors
- water soluble
- atomic force microscopy