Drug tolerability and reasons for discontinuation of seven biologics in 4466 treatment courses of rheumatoid arthritis-the ANSWER cohort study.

Kosuke EbinaMotomu HashimotoWataru YamamotoToru HiranoRyota HaraMasaki KatayamaAkira OnishiKoji NagaiYonsu SonHideki AmuroKeiichi YamamotoYuichi MaedaKoichi MurataSadao JinnoTohru TakeuchiMakoto HiraoAtsushi KumanogohHideki Yoshikawa

Published in: Arthritis research & therapy (2019)

TCZ showed the lowest discontinuation rate by lack of effectiveness, ABT showed the lowest discontinuation rate by toxic adverse events, ADA and IFX showed the highest discontinuation rate by remission, and ABT showed the highest overall retention rates (excluding non-toxic reasons and remission) among seven bDMARDs in the adjusted model.

Keyphrases

rheumatoid arthritis
disease activity
randomized controlled trial
systematic review
systemic lupus erythematosus
open label
clinical trial
combination therapy
drug induced
study protocol