Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE randomized controlled trial.
null nullMarcus AchisonSimon AdamsonAsangaedem AkpanTerry AsprayAlison AvenellMargaret M BandTufail BashirLouise A BurtonVera CvoroPeter T DonnanGordon W DuncanJacob GeorgeAdam L GordonCelia L GregsonAdrian HapcaEmily HendersonCheryl HumeThomas A JacksonPaul KempSimon KerrAlixe KilgourVeronica LyellTahir MasudAndrew McKenzieEmma McKenzieHarnish PatelKristina PilvinyteHelen C RobertsChristos RossiosAvan A SayerKaren T SmithRoy L SoizaClaire J StevesAllan D StruthersDeepa SumukadasDivya TiwariJulie WhitneyMiles D WithamPublished in: Journal of cachexia, sarcopenia and muscle (2022)
Neither perindopril nor leucine improved physical performance or muscle mass in this trial; meta-analysis did not find evidence of efficacy of either ACE inhibitors or leucine as treatments to improve physical performance.