Glucose-6-phosphatase Expression-Mediated [18F]FDG Efflux in Murine Inflammation and Cancer Models.
Mi Jeong KimChul-Hee LeeYoungeun LeeHyewon YounKeon Wook KangJoonHo KwonAbass AlaviSean CarlinGi Jeong CheonJune-Key ChungPublished in: Molecular imaging and biology (2020)
There was no difference in the pattern of [18F]FDG accumulation with time in MDA-MB-231 tumors and inflammatory lesions. We found that [18F]FDG efflux accelerated in activated macrophages reflecting increased G6Pase expression after activation and lower expression of HK II protein than that in MDA-MB-231 cancer cells.