Chronic alcohol intake regulates expression of SARS-CoV2 infection-relevant genes in an organ-specific manner.
Marion M FriskeFrancesco GiannoneMona SengerRobin SeitzAnita C HanssonRainer SpanagelPublished in: Alcoholism, clinical and experimental research (2023)
We conclude that alcohol-induced upregulation of Ace2 gene expression can lead to an elevated stochastic probability of virus entry into cells and may thus confer a molecular risk for SARS-CoV2 infection.
Keyphrases
- gene expression
- poor prognosis
- induced apoptosis
- respiratory syndrome coronavirus
- alcohol consumption
- cell cycle arrest
- dna methylation
- high glucose
- drug induced
- diabetic rats
- signaling pathway
- genome wide
- cell proliferation
- angiotensin ii
- oxidative stress
- cell death
- angiotensin converting enzyme
- endoplasmic reticulum stress
- genome wide identification
- single molecule
- bioinformatics analysis