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Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells.

Makanjuola OgunsinaPranati SamadderTemilolu IdowuGilbert ArthurFrank Schweizer
Published in: Journal of medicinal chemistry (2017)
We describe metabolically inert l-glucosamine-based glycosylated antitumor ether lipids (L-GAELs) that retain the cytotoxic effects of the D-GAELs including the ability to kill BT-474 breast cancer stem cells (CSCs). When compared to adriamycin, cisplatin, and the anti-CSC agent salinomycin, L-GAELs display superior activity to kill cancer stem cells (CSCs). Mode of action studies indicate that L-GAELs like the D-GAELs kill cells via an apoptosis-independent mechanism that was not due to membranolytic effects.
Keyphrases
  • cancer stem cells
  • cell cycle arrest
  • induced apoptosis
  • endoplasmic reticulum stress
  • oxidative stress
  • cell death
  • fatty acid
  • case control