Protein Phosphatase 5 Contributes to the Overexpression of Epigenetically Regulated T-Lymphocyte Genes in Patients with Lupus.
D PatelG GorelikB RichardsonPublished in: Lupus (Los Angeles) (2016)
The results indicate that PP5 increases expression of methylation sensitive T cell genes, and may contribute to the aberrant gene expression in CD4+CD28+ T cells that characterize lupus flares as well as the aberrant gene expression in CD4+CD28- T cells that promote atherosclerosis.
Keyphrases
- gene expression
- genome wide
- dna methylation
- systemic lupus erythematosus
- disease activity
- transcription factor
- poor prognosis
- genome wide identification
- bioinformatics analysis
- binding protein
- cardiovascular disease
- nk cells
- cell proliferation
- rheumatoid arthritis
- peripheral blood
- genome wide analysis
- type diabetes
- long non coding rna
- small molecule