Human Nasal Inferior Turbinate-Derived Neural Stem Cells Improve the Niche of Substantia Nigra Par Compacta in a Parkinson's Disease Model by Modulating Hippo Signaling.

Junwon ChoiSun Wha ParkHyunji LeeDo Hyun KimSung Won Kim

Published in: Tissue engineering and regenerative medicine (2024)

hNTSCs improved the survival rate of dopaminergic neurons by manipulating the hippocampal pathway through Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding motif (TAZ) by reducing inflammatory cytokines. In this study, we found that controlling the niche of hNTSCs had a therapeutic effect on PD lesions.

Keyphrases

neural stem cells
endothelial cells
gene expression
spinal cord
transcription factor
induced pluripotent stem cells
oxidative stress
pluripotent stem cells
binding protein
heat shock protein