Fascin-1 expression is associated with neuroendocrine prostate cancer and directly suppressed by androgen receptor.

Anthony TurpinCarine DelliauxPauline ParentHortense ChevalierCarmen Escudero-IriarteFranck BonardiNathalie VanpouilleAnne FlourensJessica QuerolAurélien CarnotXavier LeroyNicolás HerranzTristan LanelArnauld VillersJonathan OlivierHélène TouzetYvan de LaunoitTian V TianMartine Duterque-Coquillaud

Published in: British journal of cancer (2023)

Collectively, our findings identify FSCN1 as an AR-repressed gene. Particularly, it is involved in NEPC aggressiveness. Our results provide the rationale for the future clinical development of FSCN1 inhibitors in NEPC patients.

Keyphrases

prostate cancer
end stage renal disease
chronic kidney disease
newly diagnosed
ejection fraction
poor prognosis
peritoneal dialysis
prognostic factors
gene expression
current status
patient reported outcomes
binding protein
patient reported