Hyper Mucinous Proliferations in the Mucosa of Patients with Inflammatory Bowel Disease: Histological Lesions with a Real Potential for Neoplastic Evolution?
Enrico Costantino FalcoDavide Giuseppe RibaldoneGabriella CanavesePublished in: Diagnostics (Basel, Switzerland) (2024)
The present monocentric retrospective study was conducted on surgical samplings with well oriented crypts. Collected data show that hyper mucinous features are frequent occurrences in raised lesions in IBD patients. In hyper mucinous proliferations of the selected cases, the status of the proliferative cycle, the expression of the proteins most frequently involved in carcinogenetic pathways of mucosa affected by IBD, and the mucins subtypes expression have no evident anomalies. Findings are not consistent with the increased risk of neoplastic evolution observed in other studies; rather, they suggest a hyperplastic nature. However, the capacity of hyper mucinous raised lesions for neoplastic evolution should be ruled out with more extensive prospective studies to identify functional defects that could explain the hypothesized neoplastic potential.
Keyphrases
- low grade
- poor prognosis
- patients with inflammatory bowel disease
- end stage renal disease
- ejection fraction
- high grade
- chronic kidney disease
- newly diagnosed
- case control
- peritoneal dialysis
- long non coding rna
- ulcerative colitis
- human health
- electronic health record
- machine learning
- big data
- climate change
- deep learning