Citrullination is linked to reduced Ca 2+ sensitivity in hearts of a murine model of rheumatoid arthritis.
Gianluigi PirontiStefano GastaldelloDilson E RassierJohanna T LannerMattias CarlstromLars H LundHåkan WesterbladTakashi YamadaDaniel C AnderssonPublished in: Acta physiologica (Oxford, England) (2022)
sensitivity, increased expression of PAD2, and citrullination of α-actin, which was triggered by TNF-α. This provides molecular and physiological evidence for acquired cardiomyopathy and a potential mechanism for RA-associated heart failure.