ER stress aggravates diaphragm weakness through activating PERK/JNK signaling in obesity hypoventilation syndrome.
Xiaoxin XiangYanhua ZhuXuya PanWei XinJianning ChenWeijian TangRuo-Mi GuoWu YuanXuemin HeLi ZhouZhitao RenSiying WenHeting WangYan LuShasha LiTufeng ChenYuqi ZhouZulin DouMengyin CaiXiaoyue ZhangYanming ChenGuojun ShiPublished in: Obesity (Silver Spring, Md.) (2023)
These data suggest that ectopic lipid deposition impairs the diaphragmatic function of people with obesity. Activation of PERK/JNK signaling is involved in the pathogenesis of lipotoxicity-induced diaphragm weakness in obesity hypoventilation syndrome.
Keyphrases
- insulin resistance
- metabolic syndrome
- weight loss
- signaling pathway
- high fat diet induced
- type diabetes
- weight gain
- endoplasmic reticulum stress
- cell death
- induced apoptosis
- case report
- positive airway pressure
- adipose tissue
- electronic health record
- skeletal muscle
- machine learning
- physical activity
- big data
- fatty acid
- sleep apnea