Deep brain stimulation for Alzheimer's disease - current status and next steps.
Benjamin DavidsonArtur VetkasJürgen GermannDavid Tang-WaiAndres M LozanoPublished in: Expert review of medical devices (2024)
Looking ahead, a phase-3 DBS-f trial, and the prospect of closed-loop stimulation using EEG-derived biomarkers or hippocampal theta activity are highlighted. Recent FDA-approved therapies and other neuromodulation techniques like temporal interference and low-intensity ultrasound are considered. The article concludes by underscoring the importance of imaging-based diagnosis and staging to allow for circuit-targeted therapies, given the heterogeneity of AD and varied stages of neurocircuit dysfunction.
Keyphrases
- deep brain stimulation
- current status
- parkinson disease
- working memory
- obsessive compulsive disorder
- high resolution
- magnetic resonance imaging
- study protocol
- lymph node
- phase iii
- single cell
- cognitive decline
- functional connectivity
- clinical trial
- phase ii
- oxidative stress
- pet ct
- resting state
- drug administration
- cerebral ischemia
- randomized controlled trial
- ultrasound guided
- prefrontal cortex
- open label
- mass spectrometry
- fluorescence imaging
- mild cognitive impairment
- high density
- double blind