Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero.
Malin HedlundGudny Ella ThorlaciusMargarita IvanchenkoVijole OttossonNikolaos KyriakidisLinda LagnefeldtJoanna TingströmAllan SirsjöAnders A BengtssonEmma AronssonKristina Gemzell-DanielssonLars RonnblomGunnar BergmanAlexander EspinosaSven-Erik SonessonMaija-Leena ElorantaMarie Wahren-HerleniusPublished in: RMD open (2021)
Ro/La autoantibody-exposed neonates at risk of CHB have signs of an activated immune system with an IFN signature. This study further demonstrates that neonatal cells can produce IFNα when exposed to autoantibody-containing plasma, and that maternal immunomodulatory treatment may diminish the expression of IFN-regulated genes in the fetus.