Rat enteric glial cells express novel isoforms of Interleukine-7 regulated during inflammation.

Laetitia KermarrecTony DurandJacques GonzalesJulie PaboisPhilippe HulinMichel NeunlistIsabelle NeveuPhilippe Naveilhan

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)

IL-7 and its variants are expressed by neurons and glial cells in the enteric nervous system. Their distinct expression and upregulation in inflammatory conditions suggest a role in gut homeostasis which could be critical in case of chronic inflammatory diseases.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
poor prognosis
neuropathic pain
spinal cord
endoplasmic reticulum stress
signaling pathway
cell proliferation
cell death
gene expression
dna methylation
binding protein
long non coding rna