A dose-related positive effect of inhaled simvastatin-loaded PLGA nanoparticles on paraquat-induced pulmonary fibrosis in rats.

Nasrin Shahabadi Mohammad Moshiri Ali Roohbakhsh Mohsen Imenshahidi Maryam Hashemi Fatemeh Amin Rezvan Yazdian-Robati Zahra Salmasi Leila Etemad

Published in: Basic & clinical pharmacology & toxicology (2022)

Taken together, the present work provides us an idea about the pulmonary delivery of PLGA-SV NPs using nebulizer for the treatment of PQ poisoning. However, the efficacy of this formulation in human beings and clinical use needs to be more investigated.

Keyphrases

drug delivery
pulmonary fibrosis
endothelial cells
drug release
high glucose
cancer therapy
pulmonary hypertension
cystic fibrosis
drug induced
induced pluripotent stem cells
pluripotent stem cells
mass spectrometry
stress induced