A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (fu,cell).

Andrea TreyerSandra WaldayHinnerk BorissPär Matsson Per Artursson

Published in: Pharmaceutical research (2019)

We conclude that cellular PL composition varies between cell types and that cell-specific mixtures of PLs can replace cellular assays for determination of fu,cell as a rapid, small-scale assay covering a broad dynamic range. Graphical Abstract.

Keyphrases

single cell
cell therapy
cell free
high throughput
fatty acid
ionic liquid
high resolution
molecularly imprinted
drug induced