Effects of Quinacrine on Expression of Hippo signaling Pathway Components (LATS1, LATS2, and YAP) in Human Breast Cancer Stem Cells.

Soroush Darbankhales Reza Mirfakhraie Hossein Ghahremani Mohsen Asadolahi Kobra Saket-Kisomi Lily Safakish Sepideh Darbeheshti Zahra Ganjkhanlou Siamak Salami Majid Sirati-Sabet

Published in: Asian Pacific journal of cancer prevention : APJCP (2020)

MDA-MB 231 cells was treated with 0.5 µM of quinacrine for 3 days. The dose was selected using MTT assays. The expression of genes was quantified by Real-time PCR. The protein expression was performed by Western blotting. Significance of observations were checked by means of Mann-Whitney test using p.

Keyphrases

poor prognosis
cancer stem cells
induced apoptosis
signaling pathway
real time pcr
cell cycle arrest
endothelial cells
pi k akt
binding protein
endoplasmic reticulum stress
genome wide
cell death
high throughput
epithelial mesenchymal transition
gene expression
oxidative stress
cell proliferation