Anesthesia and analgesia for common research models of adult mice.
Siavash Ahmadi-NoorbakhshMohammad Farajli AbbasiMaedeh GhasemiGholamreza BayatNahid DavoodianEhsan Sharif-PaghalehSeyedeh Mahsa PoormoosaviMelika RafizadehMaryam MalekiHesamaddin Shirzad-AskiHossein Kargar JahromiMasoomeh DadkhahBahman KhalvatiTahereh SafariMohammad Amin BehmaneshSeyed Esmaeil KhoshnamGholamreza HoushmandSayyed Alireza TalaeiPublished in: Laboratory animal research (2022)
Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals and published articles. In many cases, it seems "anesthesia" and "analgesia" are used interchangeably, while they are referring to two different concepts. Not only this is an unethical practice, but also it may be one of the reasons for the proven suboptimal quality of many animal researches. This is a widespread problem among investigations on various species of animals. However, it could be imagined that it may be more prevalent for the most common species of laboratory animals, such as the laboratory mice. In this review, proper anesthetic/analgesic methods for routine procedures on laboratory mice are discussed. We considered the available literature and critically reviewed their anesthetic/analgesic methods. Detailed dosing and pharmacological information for the relevant drugs are provided and some of the drugs' side effects are discussed. This paper provides the necessary data for an informed choice of anesthetic/analgesic methods in some routine procedures on laboratory mice.
Keyphrases
- high fat diet induced
- pain management
- neuropathic pain
- systematic review
- postoperative pain
- clinical practice
- ultrasound guided
- anti inflammatory
- primary care
- emergency department
- randomized controlled trial
- insulin resistance
- wild type
- spinal cord injury
- adipose tissue
- machine learning
- case control
- big data
- adverse drug